Ketamine Therapy for Depression
286 vetted providers offer ketamine for depression. They are sorted by city below, and every other option is one click away.
Esketamine, sold as Spravato, is FDA-approved for depression that has not responded to treatment. IV ketamine is off-label but has been used in clinics for years when standard medication has not helped. Its stand-out feature is speed. Many people feel lighter within hours or days, while a regular antidepressant can take weeks.
Ketamine therapy means small, controlled doses given under medical supervision. It can be an IV drip, a shot, or Spravato nasal spray. It acts on glutamate, a different brain system from the one most antidepressants target. That is why it sometimes helps when other treatments have not, by breaking up the stuck patterns that keep depression going.
Here, ketamine belongs to the Progressive side of whole-person care. Good clinics do not offer it as a one-time fix. They combine it with therapy and stay in touch with your current prescriber, so the quick relief has support to last.
More depression treatments to compare: TMS (Transcranial Magnetic Stimulation) · EMDR Therapy · Somatic & Body-Based Therapy, or the full list for depression.
Ketamine care in New York, NY
12 listed for this city.
- Ketamine For Anxiety & Depression
- Fountain Health NYC | NYC Ketamine Therapy, Mental Health & Wellness Care
- NY Ketamine Infusions
- Keta Medical Center | Ketamine Therapy | Spravato
- Wele Clinic | Ketamine & Spravato Treatment NYC
- Nushama Wellness Center | Ketamine Therapy NYC | Spravato
- Being Health - Manhattan | Psychiatry, Spravato®, Psychotherapy & Wellness
- Hudson Mind | New York | Spravato | IV Ketamine | SGB
- Keta Medical Center | Ketamine Therapy | Spravato
- Ketamine-Assisted Psychotherapy at Integritas
- Lenox Hill Mind Care | TMS Therapy & Ketamine Treatment
- Ember Health - Upper East Side | Ketamine Therapy NYC
Ketamine care in Los Angeles, CA
7 listed for this city.
- Ketamine Healing Clinic of Los Angeles
- Felicity Mental Health Ketamine Therapy - Century City
- Pacific Mind Health – Psychiatry, TMS, Spravato & Ketamine
- Stella Mental Health (formerly Bespoke Treatment) - IOP, Ketamine & TMS Therapy - Santa Monica
- IV Hydration, Vitamin, NAD, Ketamine, Glutathione Mobile & Office Intravenous Therapy | COVID-19 PCR Testing
- Westside Mind Health Ketamine Clinic
- Ketamine Therapy Center - Cedars Sinai East Tower
Ketamine care in Boulder, CO
5 listed for this city.
- Psychedelic Growth - Ketamine and Psilocybin Therapy
- The Untitled Mind Ketamine & Integrative Psychiatry
- Suniasol Integrative Mental Health & Ketamine Clinic
- Heart & Meaning: Dr. Sasha Raskin, LPC. Individual, couples & family therapy & Ketamine Assisted Psychotherapy
- Delos Psychiatry - Integrative Psychiatry and Ketamine
Ketamine care in Seattle, WA
5 listed for this city.
Ketamine care in Santa Monica, CA
5 listed for this city.
Ketamine care in Denver, CO
4 listed for this city.
Ketamine care in Orlando, FL
4 listed for this city.
Ketamine care in Nashville, TN
4 listed for this city.
Ketamine care in Greenville, SC
4 listed for this city.
Ketamine care in Sarasota, FL
4 listed for this city.
Ketamine care in Austin, TX
4 listed for this city.
Ketamine care in Overland Park, KS
3 listed for this city.
Ketamine care for depression: questions people ask
Is ketamine approved for depression?
Esketamine nasal spray (Spravato) is FDA-approved for treatment-resistant depression. IV ketamine is off-label but has years of clinical use for depression that standard medication has not eased. Ask a clinic which form it offers.
How quickly does it work?
Many people feel a change within hours or a few days of their first sessions. A standard antidepressant often takes weeks. Clinics usually start with a set series, then move to less frequent maintenance visits.
Does insurance cover it?
Spravato is covered more and more often for treatment-resistant depression. IV ketamine is often paid out of pocket. Prices and coverage differ from clinic to clinic, so ask when you call.
Who should avoid ketamine?
It does not suit everyone. Good clinics check your blood pressure, certain mental health conditions and any history of substance use before you start. That decision belongs in a consultation with a clinician.
Want to weigh more choices? See every depression option in the US, from traditional to alternative to progressive care, or search the full Whole Wellbeing Atlas directory.